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KMID : 0928520100200020245
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Korean Journal of Lipidology
2010 Volume.20 No. 2 p.245 ~ p.253
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Korean Panax Red Ginseng Improves Muscular Arterial Stiffness in Patients with Coronary Artery Disease
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Chung Ick-Mo
Shin Gil-ja
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Abstract
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Korean Red Ginseng (KRG) is known to enhance endothelium-dependent vasorelaxation in experimental animals. However little is known about the pharmacological effect of KRG on the vascular stiffness, one of the prognostic factor for cardiovascular outcome, in patients with coronary artery disease (CAD). This study, a prospective randomized double-blind placebo-controlled trial, has been carried out to know if KRG has any effect on the blood pressure (BP), vascular stiffness, high-sensitivity C-reactive protein (hs-CRP), and plasma lipoproteins. Patients (n=17, 9 males, mean 62.5 yr) with stable angina pectoris took KRG (2.7 g/d) or placebo for 10 weeks. Compared with baseline data, KRG significantly decreased systolic BP (141±7 mmHg vs. 129±7 mmHg, P<0.05) and femoral ankle-PWV (1180.5±78.0 cm/s vs. 1021.6±70.1 cm/s, P<0.05), but not heart carotid-PWV. KRG modestly decreased total cholesterol (198.4±13.2 vs. 174.6±11.3, P=0.068) and LDL cholesterol (142.0±11.2 vs. 102.5±15.2, P=0.068) with borderline significance, but did not significantly change triglyceride, HDL cholesterol, and hsCRP. Placebo did not significantly change any of these indices. In conclusions, KRG reduces peripheral muscular arterial stiffness and systolic BP in patients with CAD, but it has neutral or modest, if any, effects on plasma lipid profile.
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KEYWORD
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Ginseng, Blood pressure, Coronary artery disease, Vascular stiffness, Cholesterol.
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